Comprehension usually used with of. Understanding a concept means you get it. Knowledge about a subject, situation, etc.
What is pseudoscience?
The meaning of understanding is a mental grasp : He noted bond's apparent lack of. Understanding is a relation between the knower and an object of understanding.
Understanding implies abilities and dispositions with respect to an object.
Or about how something works: Your understanding might be that your mother will always drive you to school if you miss the bus. How to use understanding in a sentence. Both comprehension and understanding can be used to talk about someone's ability to understand something.